Treatment Order for Patients with HER2+ Metastatic Breast Cancer After Second Line of Therapy

After progressing on trastuzumab deruxtecan (T-DXd), the discussion shifts to exploring alternative treatment options. Bhave inquires Spring about the potential use of the tucatinib/trastuzumab/capecitabine (HER2CLIMB) regimen in the second-line setting.

Spring explains that typically, the HER2CLIMB regimen is reserved for patients with progressive brain metastases due to its impressive CNS activity. However, emerging data also indicates that T-DXd has significant CNS penetration. For patients without brain metastases, Spring usually opts for T-DXd as a second-line treatment and reserves HER2CLIMB for later lines.

Bhave concurs and outlines her usual sequence of T-DXd as second-line, followed by HER2CLIMB as third-line, and then considering other options like tyrosine kinase inhibitors (TKIs) with capecitabine, or T-DM1 despite the lack of data post-T-DXd. She asks Spring about her strategy for the third-line and beyond.

Spring emphasizes the scarcity of data to definitively guide sequencing post-T-DXd and HER2CLIMB. Factors such as disease progression rate, metastatic sites, and previous response durations can assist in deciding between chemotherapy plus anti-HER2 therapy or attempting T-DM1. For patients with brain metastases, Spring suggests considering capecitabine due to its CNS activity.

Both experts agree on the numerous options available, including TKIs, chemotherapy/anti-HER2 combinations, and margetuximab. However, there is limited data on the optimal sequencing, underscoring the need for more evidence in later treatment lines. Ultimately, a tailored approach is necessary based on each patient’s specific disease characteristics and prior treatments.


More from this stream


10 Advantages of Blockchain Technology for Businesses

Most of the businesses in USA look for new methods and strategies to improve their operations and stay ahead of the competition. Blockchain technology, known for its role in supporting cryptocurrencies like Bitcoin, also offers several practical advantages for businesses across various industries. Let’s look at the stats below that support the above statement. According […]

The post Top 10 Benefits of Blockchain Technology for Business appeared first on Insights Success.

The Impact of Case Management Solutions on Client Satisfaction

The relationships between personal injury law firms and their clients are crucial for building a positive reputation and attracting future business. Poorly managed relationships can damage a reputation and lead to lost opportunities. Did you know that 78% of clients are more likely to recommend a firm that offers excellent service? Yet, balancing case management […]

The post How Case Management Solutions Impact Client Satisfaction? appeared first on Insights Success.

Handling HR Processes: Tips for Small Businesses

Handling human resources processes can be challenging for small businesses. Efficient management of HR tasks is crucial for success and employee satisfaction. Proper HR practices contribute to a positive work environment and legal compliance, making it essential for small business owners to understand these processes. By implementing effective HR strategies, small businesses can attract and […]

The post Tips for Small Businesses on Handling HR Processes appeared first on Insights Success.

Forecast of the American Auto Market for the Upcoming Fiscal Year

The American car market does not always have a stable structure, so it is challenging to forecast further changes accurately. Nevertheless, it now demonstrates a specific stability which makes it possible to assess its condition more accurately in the future. In the next fiscal year, several trends are expected to characterize the American auto market […]

The post US Auto Market Forecast For The Next Fiscal Year appeared first on Insights Success.

Comparing a Localization Platform with Traditional Localization Methods

Effectively bridging linguistic and cultural gaps is key for businesses looking to expand into new markets in today’s interconnected world of business. For years, businesses have relied on linguists to manually translate content to achieve this goal. But with the rapid advancement of technology, modern localization platforms now provide a more dynamic solution. These platforms […]

The post Localization Platform vs. Traditional Localization Methods: A Comparative Analysis appeared first on Insights Success.

Broadcom’s Stock Soars on Strong Q2 Performance and Plans for Stock Split

Broadcom (AVGO) stock surged on Thursday following a strong earnings report and news of an upcoming 10-for-1 stock split. At least 19 Wall Street firms raised their price targets for Broadcom after the company’s quarterly report late Wednesday. Jordan Klein, a trading desk analyst at Mizuho Securities, noted that Broadcom’s report would likely intensify “fear […]

The post Broadcom Stocks Jump on AI-Driven Q2 Performance, Indicates Stock Split appeared first on Insights Success.